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Your search for "fraction free drug actually increases" returned 385 results the higher free‐fraction of R ... and pharmacokinetics of a racemic drug
- 2004 - Medical - 696 pagesUnder circumstances in which only the unbound drug can be cleared by the liver ( "restrictive clearance"), free fraction and free concentration are books.google.com/books?isbn=078174380X
- 2002 - Medical - 968 pagesSimilar concentration-dependent changes in the plasma free fraction of VPA In uremia, the increase in free fraction is the result, at least in part, books.google.com/books?isbn=0781723213
, , - 2008 - Health & Fitness - 923 pagesIn neonates and young infants, a reduction in total plasma proteins can result in the availability of active drug due to an increase in the free fraction of books.google.com/books?isbn=1550093614
, , - 2007 - Health & Fitness - 1377 pagesAs the drug concentration in the plasma increases, the number of available free sites decreases; therefore, the fraction of available free drug increases. books.google.com/books?isbn=0781768799
, - 2006 - Medical - 903 pagesFor many anesthetic drugs that are highly protein bound (free fraction <20%), there is a nearly linear change in free fraction with changes in protein books.google.com/books?isbn=0323037070
4 Feb 2007 Saturation of protein binding increases the free fraction of drug which can interact with receptors and produce pharmacological effects
2005 - Medical - 2393 pagesThere are several methods by which drug protein-binding may be described quantitatively, though the most frequent and useful is the free fraction, /„. books.google.com/books?isbn=0781746736
, , - 2008 - Medical - 463 pagesAlthough the total amount of absorbed drug reaching the systemic circulation is Although the increase in the free fraction of phenytoin with age is books.google.com/books?isbn=1585281670
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